Sulfuric Acid → HCID 67331500、化合物

HRID 64000ノート

反応式

HRID 64000 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([NH:23][C:24]([N:26]3[CH2:29][CH:28]([O:30][CH3:31])[CH2:27]3)=[O:25])=[C:16]2[N:15]=1.[S:32](=[O:36])(=[O:35])([OH:34])[OH:33]>CO>[S:32]([OH:36])([OH:35])(=[O:34])=[O:33].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([NH:23][C:24]([N:26]3[CH2:27][CH:28]([O:30][CH3:31])[CH2:29]3)=[O:25])=[C:16]2[N:15]=1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 58386276(R)-N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methoxyazetidine-1-carboxamide

生成物 1

HCID 67331500HCID 67331500、化合物収率 94%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of (R)—N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methoxyazetidine-1-carboxamide (6.2 mg, 0.014 mmol) in methanol (1 mL) at ambient temperature was added sulfuric acid in methanol (145 μL, 0.014 mmol). The resulting solution was stirred for 30 minutes then concentrated to provide (R)—N-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-methoxyazetidine-1-carboxamide sulfate (7.2 mg, 0.014 mmol, 94% yield) as a yellow solid.

後処理

  1. concentrationthen concentrated

出典と根拠

ORDレコード
ord-a3071e1c621544b494cdb0e0eb20fa49
出典データセット
uspto-grants-2016_09
特許番号
US09447104B2

反応ノート

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