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Cyclamate → Cyclohexylsulfamyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclamate | HCID 7533 | — |
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Cyclohexylsulfamyl chloride | HCID 12914615 | 82.5% |
反応手順
Under a nitrogen atmosphere, a solution of N-cyclohexylsulfamic acid (50 g, 279 mmol) and PCl5 (58.1 g, 279 mmol) in 150 mL of toluene is very gently warmed up to 100° C. and maintained at that temperature for 1 hour. Distillation of the solution yields N-cyclohexylsulfamoyl chloride as a colorless solid (45.5 g, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691929B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-ade2508b1acf415787124703329b534f |
| 出典メモ | uspto-grants-2010_04 |