Hydrochloric Acid → (E)-1-(Benzyloxy)-4-(2-nitrovinyl)benzene

To a mixture of 4-benzyloxybenzaldehyde (1.0 g, 4.7 mmol) and sodium methoxide (28% methanol solution, 150 μL, 0.74 mmol) and methanol (10 mL) were added nitromethane (330 μL, 6.1 mmol) and sodium methoxide (28% methanol solution, 1.0 mL, 4.9 mmol) at 0° C., which was stirred for 10 minutes at room temperature. The reaction mixture was cooled to 0° C., and 5 N aqueous hydrochloric acid solution (20 mL) was added thereto at the same temperature. The reaction mixture was then stirred for 15 minutes at room temperature. The precipitated solids were filtered to obtain the title compound (1.2 g, 100%).

1. temperatureThe reaction mixture was cooled to 0° C.
2. stirringThe reaction mixture was then stirred for 15 minutes at room temperature
3. filtrationThe precipitated solids were filtered

ORDレコード

ord-3dedb112fb704cc2a400c83b2e7b1cce

出典データセット

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07691882B2