(4-(2-Furan-2-yl-ethyl)-phenyl)-methanol → HCID 59255346、化合物

HRID 640312ノート

反応式

HRID 640312 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][CH:9]=1>[O-2].[O-2].[Mn+4].C(OCC)(=O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([CH:14]=[O:15])=[CH:12][CH:13]=1

参加物

4

反応物 1

HCID 59255362(4-(2-Furan-2-yl-ethyl)-phenyl)-methanol

生成物 1

HCID 59255346HCID 59255346、化合物収率 83.5%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

To an ethyl acetate (50 mL) solution of (4-(2-furan-2-yl-ethyl)-phenyl)-methanol (580 mg, 2.87 mmol) described in Manufacturing Example 80-1-3 was added activated manganese dioxide (8 g, 92 mmol), which was stirred for 12 hours at room temperature. The reaction solution was suction filtered through a Celite pad, and washed with ethyl acetate (50 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (480 mg, 83.5%).

後処理

  1. filtrationfiltered through a Celite pad
  2. washwashed with ethyl acetate (50 mL)
  3. concentrationThe filtrate was concentrated under a reduced pressure

出典と根拠

ORDレコード
ord-c5e60748a0104d8eb344dd56fd719a57
出典データセット
uspto-grants-2010_04
特許番号
US07691882B2

反応ノート

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