(2-Amino-6-methylpyridin-3-yl)methanol → 2-Amino-6-methylnicotinaldehyde

HRID 640461ノート

反応式

HRID 640461 の反応式
[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[C:4]([CH3:10])[N:3]=1>[O-2].[O-2].[Mn+4].C(Cl)Cl>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([CH3:10])[N:3]=1

参加物

4

反応物 1

HCID 55281422(2-Amino-6-methylpyridin-3-yl)methanol

生成物 1

HCID 534010302-Amino-6-methylnicotinaldehyde収率 88%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

To a methylene chloride (8 mL) solution of (2-amino-6-methyl-pyridin-3-yl)-methanol (379 mg, 2.74 mmol) described in Manufacturing Example 170-1-3 was added manganese (IV) dioxide (1.19 mg, 13.7 mmol) at room temperature, which was stirred for 11 hours at room temperature. The reaction mixture was filtered through a Celite pad, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:2) to obtain the title compound (328 mg, 88%).

後処理

  1. filtrationThe reaction mixture was filtered through a Celite pad
  2. concentrationthe filtrate was concentrated under a reduced pressure
  3. customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:2)

出典と根拠

ORDレコード
ord-ad4bbb720b8b4f2d90e64f8e403e1573
出典データセット
uspto-grants-2010_04
特許番号
US07691882B2

反応ノート

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