反応式
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2OCC[O:15]2)=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[CH2:1]([C:8]1[N:9]=[CH:10][C:11]([CH:14]=[O:15])=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
3
反応条件
- 温度
- 100 °C
実験手順
2-Benzyl-5-[1,3]dioxolan-2-yl-pyridine (7.3 g, 30 mmol) described in Manufacturing Example 210-1-3 and 2 N hydrochloric acid (100 mL) were stirred for 55 minutes at 100° C. The reaction solution was cooled to room temperature and partitioned into ethyl acetate and a 5 N sodium hydroxide solution (40 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered.
後処理
- temperatureThe reaction solution was cooled to room temperature
- custompartitioned into ethyl acetate
- customThe organic layer was separated
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-549e0a2da0cb42c781b173e9e098a100
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07691882B2
関連ノート
読み込み中…