Ethyl 4-ethyl-1-piperazineacetate → (4-ethylpiperazin-1-yl)acetic acid
反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]([O:12]CC)=[O:11])[CH2:5][CH2:4]1)[CH3:2]>Cl>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]([OH:12])=[O:11])[CH2:5][CH2:4]1)[CH3:2]参加物
3
実験手順
The solution of ethyl 2-(4-ethylpiperazin-1-yl)acetate (1.3 g, 6.50 mmol, 1.0 eq) in 8 N HCl stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump, and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54.5% yield (0.6 g).
後処理
- concentrationThe mixture was concentrated on vacuum pump
- customquenched
- extractionextracted as in Intermediate Example 15(b)
- distillationThe solvent was distilled off
- customto afford the product in 54.5% yield (0.6 g)
出典と根拠
- ORDレコード
- ord-2dd1db6cc3964502bd4eecb320bbc4d8
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09447091B2
反応ノート
読み込み中…