1-Piperidineacetic acid, ethyl ester → Piperidin-1-yl-acetic acid

HRID 64075ノート

反応式

HRID 64075 の反応式
[N:1]1([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 6434661-Piperidineacetic acid, ethyl ester

生成物 1

HCID 201097Piperidin-1-yl-acetic acid収率 60%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The solution of ethyl 2-(piperidin-1-yl)acetate (2.4 g, 14.0 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 60% yield (1.2 g). LC-MS (ESI): Calculated mass: 143.1; Observed mass 144.4 [M+H]+ (rt: 0.21 min).

後処理

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 60% yield (1.2 g)
  6. customObserved mass 144.4 [M+H]+ (rt: 0.21 min)

出典と根拠

ORDレコード
ord-fa250c7a410a424eb9b5d41a75fb6808
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

反応ノート

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