Hydrochloric Acid → Telmisartan Hydrochloride

HRID 640750ノート

反応式

HRID 640750 の反応式
[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][CH:16]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1.[ClH:40]>CO>[ClH:40].[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:19][CH:20]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 65999Telmisartan

生成物 1

HCID 11956638Telmisartan Hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

10 g of telmisartan are suspended in 70 ml of methanol in a round-bottom flask equipped with magnetic stirrer, condenser and under nitrogen atmosphere. The solution is added with 2.0 ml of a 37% HCl aqueous solution and the mixture is heated under reflux, then cooled to room temperature. The resulting precipitate is filtered and dried under vacuum at 55° C. to obtain 7.5 g of telmisartan hydrochloride.

後処理

  1. customequipped with magnetic stirrer, condenser and under nitrogen atmosphere
  2. temperaturethe mixture is heated
  3. temperatureunder reflux
  4. filtrationThe resulting precipitate is filtered
  5. customdried under vacuum at 55° C.

出典と根拠

ORDレコード
ord-850229d9d6234a3bb62959ac022dad54
出典データセット
uspto-grants-2010_04
特許番号
US07692027B2

反応ノート

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