Ethyl 2-Morpholinoacetate → 4-Morpholineacetic acid

HRID 64077ノート

反応式

HRID 64077 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:3][CH2:2]1>Cl>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 2734105Ethyl 2-Morpholinoacetate

生成物 1

HCID 4389684-Morpholineacetic acid収率 60%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The solution of ethyl 2-morpholinoacetate (0.73 g, 4.24 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 60% yield (0.37 g). LC-MS (ESI): Calculated mass: 145.1; Observed mass 146.3 [M+H]+ (rt: 0.28 min).

後処理

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 60% yield (0.37 g)
  6. customObserved mass 146.3 [M+H]+ (rt: 0.28 min)

出典と根拠

ORDレコード
ord-1a70147cae1944d58500d429263efef5
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

反応ノート

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