1-Pyrrolidineacetic acid, ethyl ester → Pyrrolidin-1-ylacetic acid

HRID 64078

反応式

HRID 64078 の反応式
[N:1]1([CH2:6][C:7]([O:9]CC)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 2109961-Pyrrolidineacetic acid, ethyl ester

生成物 1

HCID 414564Pyrrolidin-1-ylacetic acid収率 54%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (1.8 g, 11.95 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54% yield (1.4 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H]+ (rt: 0.26 min).

後処理

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 54% yield (1.4 g)
  6. customObserved mass 130.1 [M+H]+ (rt: 0.26 min)

出典と根拠

ORDレコード
ord-51539287a7fb4cb9b67dc53ad3804551
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

関連ノート

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