1,4-Dioxane → 8-Hydroxy-quinazoline-2-carboxaldehyde

HRID 640784ノート

反応式

HRID 640784 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[N:8]=[CH:7]2.[O:13]1CCOCC1>>[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH:12]=[O:13])[N:8]=[CH:7]2

参加物

3

反応物 2

HCID 312751,4-Dioxane2 回HCID 106070502-Methylquinazolin-8-ol

生成物 1

HCID 592565308-Hydroxy-quinazoline-2-carboxaldehyde

反応条件

温度
80 °C

実験手順

A solution of 8-hydroxy-2-methyl-quinazoline (A3) (5 mmol) in dioxane (10 mL) was added dropwise over 3 h into a stirred mixture of SeO2 (8.8 mmol) in dioxane (30 mL) at 50° C. The resulting mixture was then heated at 80° C. for 16 h, allowed to cool, and the solids filtered off. The filtrate was concentrated and purified via column chromatography on silica (dichloromethane/MeOH, 40:1). This afforded 8-hydroxy-quinazoline-2-carboxaldehyde (2) as a solid.

後処理

  1. temperatureto cool
  2. filtrationthe solids filtered off
  3. concentrationThe filtrate was concentrated
  4. custompurified via column chromatography on silica (dichloromethane/MeOH, 40:1)

出典と根拠

ORDレコード
ord-d8572207320843eabcd083b04b20af2d
出典データセット
uspto-grants-2010_04
特許番号
US07692011B2

反応ノート

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