Potassium Carbonate → HCID 79362010、化合物

HRID 64079ノート

反応式

HRID 64079 の反応式
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH2:15][C:16]([CH3:19])([OH:18])[CH3:17]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])[CH:6]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 163754-BromopyrazoleHCID 106071724-Bromo-2-methylbutan-2-ol

生成物 1

HCID 79362010HCID 79362010、化合物収率 60%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 4-bromo-1H-pyrazole (1 g, 6.84 mmol, 1.0 eq) in DMF were added K2CO3 (2.3 g, 17.1 mmol, 2.5 eq.) and 4-bromo-2-methylbutan-2-ol (1.7 g, 10.27 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 60% yield (0.9 g). LC-MS (ESI): Calculated mass 233.0; Observed mass 235.0. [M+H]+ (rt: 0.64 min).

後処理

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 60% yield (0.9 g)
  5. custom[M+H]+ (rt: 0.64 min)

出典と根拠

ORDレコード
ord-5ef8ce30534a4941887a18ee3f3b4646
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

反応ノート

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