Acetic Anhydride → N-(3-bromo-5-nitrophenyl)acetamide

HRID 64084

反応式

HRID 64084 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:10]=[C:11]([CH:13]=[C:14]([N+:16]([O-:18])=[O:17])[CH:15]=1)[NH2:12]>>[Br:8][C:9]1[CH:10]=[C:11]([NH:12][C:5](=[O:7])[CH3:6])[CH:13]=[C:14]([N+:16]([O-:18])=[O:17])[CH:15]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 44535ar-Bromo-ar-nitrobenzenamine

生成物 1

HCID 10658908N-(3-bromo-5-nitrophenyl)acetamide収率 78%

実験手順

Acetic anhydride (14 ml) was added dropwise at 0° C. to 3-bromo-5-nitroaniline (14 g, 64.5 mmol). The mixture was stirred for 30 min at RT and then quenched by the addition of crushed ice. The precipitate formed was filtered and washed with cold water to obtain off-white solid. The solid was dried under vacuum to give the product in 78% yield (13 g). 1H NMR (300 MHz, DMSO-d6): δ 10.54 (br s, 1H), 8.45 (s, 1H), 8.2 (s, 1H), 8.03 (s, 1H), 2.11 (s, 3H).

後処理

  1. customquenched by the addition of crushed ice
  2. customThe precipitate formed
  3. filtrationwas filtered
  4. washwashed with cold water
  5. customto obtain off-white solid
  6. customThe solid was dried under vacuum
  7. customto give the product in 78% yield (13 g)

出典と根拠

ORDレコード
ord-e6da30ffaba741e1ab8521151fa9e3e7
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

関連ノート

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