Sodium Hydroxide → 5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Hydroxide	HCID 14798	—
反応物	N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)acetamide	HCID 71554232	—
溶媒	Ethanol	HCID 702	—
生成物	5-(5-(1-(2-(dimethylamino)ethyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]-imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine	HCID 117777662	77%

反応条件

温度	85 °C

反応手順

To a solution of the compound of Example 20 (450 mg, 0.9 mmol) in ethanol (10 ml) was added aqueous solution of NaOH (450 mg, 11.25 mmol, 12.5 eq.) and the mixture was heated at 85° C. for 2 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 77% yield (0.32 g).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09447091B2
出典データセット	uspto-grants-2016_09
ORD ID	ord-c3086a9091d54629acca513578b8af88
出典メモ	uspto-grants-2016_09