Cyclopropanesulfonyl chloride → N-(4'-fluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)cyclopropanesulfonamide

HRID 64101

反応式

HRID 64101 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([N:14]3[C:18]4[CH:19]=[CH:20][C:21]([C:23]5[CH:24]=[N:25][N:26]([CH3:28])[CH:27]=5)=[CH:22][C:17]=4[N:16]=[CH:15]3)[CH:11]=[C:10]([NH:29]C(=O)C)[CH:9]=2)=[CH:4][CH:3]=1.[CH:33]1([S:36](Cl)(=[O:38])=[O:37])[CH2:35][CH2:34]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([N:14]3[C:18]4[CH:19]=[CH:20][C:21]([C:23]5[CH:24]=[N:25][N:26]([CH3:28])[CH:27]=5)=[CH:22][C:17]=4[N:16]=[CH:15]3)[CH:11]=[C:10]([NH:29][S:36]([CH:33]3[CH2:35][CH2:34]3)(=[O:38])=[O:37])[CH:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 2760919Cyclopropanesulfonyl chlorideHCID 117777668N-(4'-fluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-biphenyl-3-yl)acetamide

生成物 1

HCID 121331757N-(4'-fluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)cyclopropanesulfonamide

実験手順

The compound was prepared from the compound of Example 53 using the procedures of Example 54 and cyclopropane sulfonyl chloride. 1H NMR (300 MHz, DMSO-d6): δ 10.28 (s, 1H), 9.1 (br s, 1H), 8.26 (s, 1H), 8.01 (d, 2H), 7.84-7.81 (m, 2H), 7.74-7.71 (m, 3H), 7.59 (s, 2H), 7.39 (t, 2H), 3.89 (s, 3H), 2.91-2.89 (m, 1H), 1.03 (d, 4H); LC-MS (ESI): Calculated mass: 487.55; Observed mass: 488.1 [M+H]+ (rt: 1.42 min).

後処理

  1. custom488.1 [M+H]+ (rt: 1.42 min)

出典と根拠

ORDレコード
ord-997cbbebaba34a45ac5aac047239fb4e
出典データセット
uspto-grants-2016_09
特許番号
US09447091B2

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