関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | L-Lactic Acid | HCID 107689 | — |
| 反応物 | (2R)-2-Hydroxy-2-methyl-3-phenylpropanoic acid | HCID 11286816 | — |
| 反応物 | HCID 178418581 | HCID 178418581 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Benzyl lactate | HCID 98054 | 95% |
反応手順
Construction of Benzyl-L-lactic Acid. L-Lactic acid (9 g, 100 mmol) is added to N,N'-diisopropylbenzylisourea (23.3 g, 100 mmol) with stirring. The mixture becomes very viscous within 10 min and is stirred intermittently for 1 h. The volume is then increased to 200 mL with THF, and the mixture stirred for 48 h at room temperature. After cooling the mixture to -15° C., the diisopropylurea is removed by filtration and the THF is evaporated under reduced pressure. The resulting thick oil is pumped under high vacuum for 24 h to give benzyl lactate (17.4 g, 95%) which may be used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05248761 |
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| 出典データセット | uspto-grants-1993_09 |
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| ORD ID | ord-9f8135fc2ea3458ea13011035828fec5 |
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| 出典メモ | uspto-grants-1993_09 |
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