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Hydrochloric Acid → 4-(Benzyloxy)-3-nitrobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Methyl 4-benzyloxy-3-nitrobenzoate | HCID 289857 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(Benzyloxy)-3-nitrobenzoic acid | HCID 16124725 | 95% |
反応手順
A solution the crude 4-benzyloxy-3-nitro-benzoic acid methyl ester from the previous step in tetrahydrofurane (150 mL) and MeOH (600 mL) was treated with KOH 3N (152 mL) and stirred at room temperature for 18 hours. The mixture was acidified with HCl 3N. The precipitate thus formed was filtered, washing with MeOH/water 1:1 and dried under vacuum. 4-Benzyloxy-3-nitro-benzoic acid (42 g, 95% over two steps) was obtained as a white solid, which was used crude in the following reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07696200B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-5455e7bbed7947c3837d891a0098e981 |
| 出典メモ | uspto-grants-2010_04 |