Piperazine → 6-(2-Fluoro-4-iodophenylamino)-1,3-dimethyl-5-(piperazine-1-carbonyl)pyrimidine-2,4(1H,3H)-dione
反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]([CH3:16])[C:14](=[O:17])[N:13]([CH3:18])[C:12](=[O:19])[C:11]=1[C:20]([O:22]C1C=CC=CC=1)=O.[NH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]([CH3:16])[C:14](=[O:17])[N:13]([CH3:18])[C:12](=[O:19])[C:11]=1[C:20]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)=[O:22]参加物
3
実験手順
Example 43 was synthesized following a similar procedure described in the synthesis of Example 5 by reaction of compound 2A and piperazine. 1H NMR (400 MHz, CDCl3) δ 7.61 (d, J=8.0 Hz, 1 H) 7.56 (d, J=8.0 Hz, 1 H) 6.99 (t, J=8.0 Hz, 1 H) 3.93 (m, 1 H) 3.77 (m, 1 H) 3.51 (s, 3 H) 3.25 (s, 3 H) 3.17 (m, 4 H) 2.98 (m, 1 H) 2.52 (m, 1 H). [M+H] calc'd for C17H19FIN5O3, 488; found, 488.
後処理
- customExample 43 was synthesized