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(4-Nitrophenyl)acetic acid → HCID 178526605、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4-Nitrophenyl)acetic acid | HCID 4661 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Chloropyridine-3,4-diamine | HCID 285736 | — |
| 生成物 | HCID 178526605 | HCID 178526605 | 76% |
反応手順
2.1 A solution of 1.44 g of 3,4-diamino-2-chloropyridine and 9.06 g of (4-nitrophenyl)acetic acid in 10 ml of polyphosphoric acid is stirred at 80° for 16 hours. The mixture is subsequently poured into ice-water, neutralised using NaOH, the deposited crystals are separated off and subjected to conventional work-up. The organic phase yields 2.2 g of 4-chloro-2-(4-nitrophenylmethyl)-3H-imidazo[4,5-c]pyridine (“4”).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07696224B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-f84631e2ee1f4c819e853d1652d6304a |
| 出典メモ | uspto-grants-2010_04 |