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Diisopropylcarbodiimide → 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylcarbodiimide | HCID 12734 | — |
| 反応物 | Benzene, 1-isothiocyanato-4-nitro- | HCID 75044 | — |
| 反応物 | 2-Chloropyridine-3,4-diamine | HCID 285736 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine | HCID 178526682 | 82.9% |
反応手順
3.1 A solution of 0.72 g of 3,4-diamino-2-chloropyridine, 0.9 g of 4-nitrophenyl isothiocyanate and 0.78 ml of N,N-diisopropylcarbodiimide in 30 ml of DMF is stirred at room temperature for 16 hours, then at 500 for 6 hours. The solvent is separated off, and the residue is crystallised from methanol, giving 1.2 g of 4-chloro-2-(4-nitrophenylamino)-3H-imidazo-[4,5-c]pyridine (“6”).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07696224B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-5af5aee4d7de41bbb82aa03f3bc06196 |
| 出典メモ | uspto-grants-2010_04 |