関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,5-Dimethyl-1-phenylpyrrole-3-carboxaldehyde | HCID 66515 | — |
| 反応物 | 6-Quinolinamine, N,N,2-trimethyl- | HCID 66725 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | Pyrvinium Pamaote Impurity 3 | HCID 25015775 | 2.1% |
反応手順
To a solution of compound 3 (316 mg, 1.7 mmol) and compound 5 (507 mg, 2.55 mmol) in DMF (25 mL) was added ZnCl2 (232 mg, 1.7 mmol). The reaction mixture was stirred at 160° C. overnight. Then the reaction mixture was diluted with aqueous NaOH (10%) and extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure, the residue was purified by column chromatography (hexane: EtOAc=20:1) to give 13 mg of the target product (2.1%). MS [M++1]=368, LC-MS: tR=1.909 min
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07696227B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-542751499db846c49ec3256d8634c523 |
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| 出典メモ | uspto-grants-2010_04 |
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