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Sodium Thiosulfate → 2-(3,4-Dimethoxyphenyl)-2-methylpropanal
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Thiosulfate | HCID 24477 | — |
| 反応物 | Triacetoxyperiodinane | HCID 159087 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 2-(3,4-Dimethoxyphenyl)-2-methylpropan-1-ol | HCID 13015778 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(3,4-Dimethoxyphenyl)-2-methylpropanal | HCID 59259113 | — |
反応手順
A solution of 100 mg (0.476 mmol) 2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol in 1 ml dichloromethane is treated with 202 mg (0.476 mmol) Dess-Martin reagent at rt. After 1 h aqueous sodium bicarbonate and sodium thiosulphate solutions are added and the product is extracted with dichloromethane. The organic layers are evaporated and the aldehyde is obtained in a sufficient purity to be used in reductive aminations.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07696216B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-dddd08e6850b4021b07f404df645263b |
| 出典メモ | uspto-grants-2010_04 |