関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 1-Phenylpyrrolidine | HCID 77726 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-(Pyrrolidin-1-YL)benzenesulfonic acid | HCID 22147101 | 47.2% |
反応手順
A solution of H2SO4 (6.8 g, 68.00 mmol) in diethylether (80 mL) was added to 1-phenylpyrrolidine (10 g, 68.03 mmol) in diethylether (20 mL) at 0° C. The diethylether was decanted, and the resulting solution was stirred for 3 hours at 170° C., then concentrated in vacuo to afford 7.3 g (43%) of 4-(pyrrolidin-1-yl)benzenesulfonic acid as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07696229B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-fcdcf67793a74eb0b5e9c1631abd2ed2 |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
