N-Methylaniline → N-Methylacetanilide

反応式

O([C:5]([CH3:7])=[O:6])C(C)=O.[CH3:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH3:8][N:9]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:5](=[O:6])[CH3:7]

参加物

反応物 2

HCID 7515N-Methylaniline

HCID 7918Acetic Anhydride

生成物 1

HCID 11364N-Methylacetanilide収率 73.7%

実験手順

(CH3CO)2O (50 g, 480.77 mmol) was added to N-methylbenzenamine (10.7 g, 100.00 mmol), and the resulting solution was stirred at room temperature for 15 hours. The reaction mixture was then quenched by adding 200 mL of iced water. The resulting solution was extracted with dichloromethane (2×100 mL), and the organic layers were combined and concentrated to afford 11 g (70%) of N-methyl-N-phenylacetamide as a white solid.

後処理

customThe reaction mixture was then quenched
additionby adding 200 mL of iced water
extractionThe resulting solution was extracted with dichloromethane (2×100 mL)
concentrationconcentrated

出典と根拠

ORDレコード: ord-ca8bdbb9d5d249b892e411cd95f5d6d2
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07696229B2

反応ノート

読み込み中…

参加物