関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Iodoisatin | HCID 88695 | — |
| 反応物 | Benzoic acid, 4-(1,1-dimethylethyl)-, hydrazide | HCID 123513 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 4-tert-butyl-N'-(5-iodo-2-oxoindol-3-yl)benzohydrazide | HCID 178440973 | 75% |
反応手順
Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-tert-butylbenzohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 168 mg of the title compound (75%) as a yellow solid in 99.8% purity by HPLC (Rt: 6.65, gradient of 10 min, MaxPlot detection between 230 and 400 nm).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07696231B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-fdbfdf3024b4465e97cbdea545049adb |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
