関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Iodoisatin | HCID 88695 | — |
| 反応物 | 4-(2-Hydrazino-2-oxoethoxy)benzoic acid | HCID 9855838 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178521411 | HCID 178521411 | 7% |
反応手順
Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-(2-hydrazino-2-oxoethoxy)benzoic acid. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 6 mg of the title compound (7%) as a yellow solid in 97.8% purity by HPLC (Rt: 3.63, gradient of 8 min, MaxPlot detection between 230 and 400 nm).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07696231B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-4cc616046cfb4ab3a5b2e3b600b04a85 |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
