5-Iodoisatin → HCID 178520488、化合物
反応式
[I:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=O.[OH:13][C:14]1[CH:15]=[C:16]([CH2:21][CH2:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]([NH:34][NH2:35])=[O:33])=[CH:28][CH:27]=2)=[O:24])[CH:17]=[CH:18][C:19]=1[OH:20]>C(O)(=O)C>[OH:13][C:14]1[CH:15]=[C:16]([CH2:21][CH2:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]([NH:34][N:35]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([I:1])[CH:3]=4)[NH:7][C:6]3=[O:11])=[O:33])=[CH:28][CH:27]=2)=[O:24])[CH:17]=[CH:18][C:19]=1[OH:20]参加物
4
反応条件
- 温度
- 100 °C
実験手順
Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 3-(3,4-dihydroxyphenyl)-N-[4-(hydrazinocarbonyl)phenyl]propanamide. After stirring at 100° C. the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 161 mg of the title compound (87%) as a yellow solid in 96% purity by HPLC (Rt: 3.56, gradient of 8 min, MaxPlot detection between 230 and 400 nm).