関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Bromoisatin | HCID 6889 | — |
| 反応物 | Methyl 4-((aminocarbamoyl)methoxy)benzoate | HCID 2759745 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178498288 | HCID 178498288 | 80% |
反応手順
Following the general method as outlined in Example 1, into a suspension of 5-bromo-1H-indole-2,3-dione in acetic acid was added methyl 4(2-hydrazino-2-oxoethoxy)benzoate. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 86 mg of the title compound (80%) as a orange powder in 94% purity by HPLC (Rt: 4.17, gradient of 8 min, MaxPlot detection between 230 and 400 nm).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07696231B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-ba222646a9754250878e4cc9a82abea4 |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
