関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Iodoisatin | HCID 88695 | — |
| 反応物 | N-[4-(hydrazinocarbonyl)phenyl]-N-methyl-3-phenylpropanamide | HCID 9814735 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178485632 | HCID 178485632 | 56% |
反応手順
Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3dione in acetic acid was added N-[4(hydrazinocarbonyl)phenyl]-N-methyl-3-phenylpropanamide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH and water and drying under vacuo at 60° C. overnight gave the title compound (226 mg, 56%) as an orange solid in 96.7% purity by HPLC (MaxPlot detection between 230 and 400 nm).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07696231B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-1651d67115414a23b1f1e5644b0678ab |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
