Methylparaben → Methyl 4-((6-methylpyridin-2-yl)methoxy)benzoate

反応式

[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.Cl.Cl[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[N:16]=1>>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[N:16]=2)=[CH:6][CH:5]=1

参加物

反応物 2

HCID 7456Methylparaben

HCID 765456-Chloromethyl-2-methylpyridinium chloride

生成物 1

HCID 914666Methyl 4-((6-methylpyridin-2-yl)methoxy)benzoate

実験手順

The title compound is prepared in a manner substantially analogous to Procedure E except KI (1.3 eq.) is also added from 4-hydroxy-benzoic acid methyl ester and 2-(chloromethyl)-6-methyl-pyridine hydrochloride [CAS 3099-29-4]. MS (ES+) 258.2

出典と根拠

ORDレコード: ord-b695783cef3a423b88f9137f84e17478
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07696234B2

反応ノート

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