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Methyl Ethyl Ketone → 3-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Ethyl Ketone | HCID 6569 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| 生成物 | 3-(4-(3,4-Dichlorophenyl)piperazine-1-yl)propan-1-ol | HCID 13097930 | — |
反応手順
Compound 5 (0.32 mL, 3.54 mmols) was mixed with 4-(3,4-dichlorophenyl)piperazine (0.58 g, 2.5 mmols) and potassium carbonate (0.78 g, 5.6 mmols) in 15 ml 2-butanone overnight at 85° C. as described in General Procedure B to yield compound 7p and was used as is for the next reaction. MS (LC/MS, ESI): 289 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447122B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-b2b44e96151540e98a8efe67154bbde0 |
| 出典メモ | uspto-grants-2016_09 |