Ethyl 2-((tert-butoxycarbonyl)amino)acetate → 4-Bromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1,5-bis-(4-fluoro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

HRID 642227

反応式

HRID 642227 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[C:7]=1[CH2:26]Br)=[O:5])[CH3:2].[CH2:28]([O:30][C:31](=[O:41])[CH2:32][NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH3:29]>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:8]([C:19]2[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=2)[C:7]=1[CH2:26][N:33]([C:34]([O:36][C:37]([CH3:38])([CH3:40])[CH3:39])=[O:35])[CH2:32][C:31]([O:30][CH2:28][CH3:29])=[O:41])=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 357729Ethyl 2-((tert-butoxycarbonyl)amino)acetateHCID 684280644-Bromo-2-bromomethyl-1,5-bis-(4-fluoro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

生成物 1

HCID 684283234-Bromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1,5-bis-(4-fluoro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

実験手順

Prepared in analogy to that of Example 1(c) from 4-bromo-2-bromomethyl-1,5-bis-(4-fluoro-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester and tert-butoxycarbonylamino-acetic acid ethyl ester. The title compound, ESI MS (m/z): 643 (M+Na+).

出典と根拠

ORDレコード
ord-d3bc6137fd3841a8bfeb39681fce6b7b
出典データセット
uspto-grants-2010_04
特許番号
US07696223B2

関連ノート

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