Water → HCID 178418590、化合物

HRID 6423

反応式

HRID 6423 の反応式
[CH:1]1[CH:6]=[C:5]([NH:7][C:8]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18]3[C:23]4[N:24]=[CH:25][N:26]([C@@H:27]5[O:31][C@H:30]([CH2:32][OH:33])[C@@H:29]([OH:34])[C@H:28]5[OH:35])[C:22]=4[N:21]=[CH:20][N:19]=3)=[CH:13][CH:12]=2)=[O:9])[CH:4]=[C:3]([CH2:36][C:37]([NH:39][CH2:40][CH2:41][NH2:42])=[O:38])[CH:2]=1.[CH3:43][C:44]1([CH3:56])[N:49]([O:50])[C:48]([CH3:52])([CH3:51])[CH2:47][CH:46](N=C=S)[CH2:45]1.O.O=C[C@@H]([C@@H]([C@@H](CO)O)O)O>CN(C=O)C>[CH3:51][C:48]1([CH3:52])[N:49]([O:50])[C:44]([CH3:56])([CH3:43])[CH2:45][CH2:46][CH2:47]1.[CH:1]1[CH:6]=[C:5]([NH:7][C:8]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([NH:17][C:18]3[C:23]4[N:24]=[CH:25][N:26]([C@@H:27]5[O:31][C@H:30]([CH2:32][OH:33])[C@@H:29]([OH:34])[C@H:28]5[OH:35])[C:22]=4[N:21]=[CH:20][N:19]=3)=[CH:15][CH:16]=2)=[O:9])[CH:4]=[C:3]([CH2:36][C:37]([NH:39][CH2:40][CH2:41][NH2:42])=[O:38])[CH:2]=1

参加物

6

反応物 4

HCID 962WaterHCID 1476454-Isothiocyanato-2,2,6,6-tetramethylpiperidinooxylHCID 5311110Aldehydo-D-riboseHCID 16218845N-[3-[2-(2-aminoethylamino)-2-oxoethyl]phenyl]-2-[4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]phenyl]acetamide2 回

生成物 1

HCID 178418590HCID 178418590、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

ADAC, 2 (11.8 mg, 20 umol), was suspended in 0.5 ml DMF and treated with 4-isothiocyanato-TEMPO (2,2,6,6,-tetramethyl-1-piperidinyloxy, free radical (7 mg, Aldrich). After 1 hour 1.5 ml water was added to the solution, and the precipitate was collected, washed with a minimum of MeOH and ether, and recrystallized from DMF/ether/petroleum ether, to give a product which was homogeneous by thin layer chromatography and gave proton NMR and ESR spectra consistent with the structure. Yield 8.3 mg (51%). Cf-MS peak at 758 (m+1-MeO) and 626 (m+1 -ribose). IR shows a peak at 1580 cm-1, characteristic of a thiourea carbonyl stretch.

後処理

  1. customthe precipitate was collected
  2. washwashed with a minimum of MeOH and ether
  3. customrecrystallized from DMF/ether/petroleum ether
  4. customto give a product which
  5. customgave proton NMR and ESR spectra consistent with the structure

出典と根拠

ORDレコード
ord-e7e3a364972640cab00e95d8a664a41d
出典データセット
uspto-grants-1993_09
特許番号
US05248770

関連ノート

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