2-Pyridin-4-yl-benzooxazol-5-ylamine → N-(2-(pyridin-4-yl)benzo[d]oxazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

関与物質

反応手順

The general procedure for compound 8 was followed using starting materials 2,3-dihydrobenzo [b][1,4]dioxine-2-carboxylic acid and compound 4 (5-thiazole) to give title compound Q20 (73%) as a white solid. 1H NMR (CDCl3, 400 MHz) δ 4.31 (dd, J, =11.6 Hz, J2=7.2 Hz, 1H), 4.66 (dd, J1=12 Hz, J2=2.8 Hz, 1H), 4.86 (dd, J, =7.4 Hz, J2=2.8 Hz, 1H), 6.93-6.96 (m, 3H), 7.06-7.08 (m, 1H), 7.59 (s, 2H), 8.07-8.08 (m, 2H), 8.14 (s, 1H), 8.43 (s, 1H), 8.83 (d, J=5.6 Hz, 2H); 13C NMR (CDCl3, 100 MHz) δ 65.5, 73.5, 111.2, 112.6, 117.3, 118.0, 119.6, 121.2, 122.3, 123.0, 134.2, 134.3, 141.5, 142.4, 143.4, 148.2, 150.9, 161.9, 165.4; ESI-HRMS for C21H16N3O4(M+H)+ calcd. 374.1141. found 374.1138.

情報源と証拠