2-Pyridin-4-yl-benzooxazol-5-ylamine → (2S)-2-phenyl-N-[2-(4-pyridyl)-1,3-benzoxazol-5-yl]propanamide

関与物質

反応手順

Similarly prepared as per compound 8, using starting materials (S)-2-phenylpropanoic acid and compound 4 (R, =2-pyridine) to obtained title compound Q48 as white solid (77%). 1H NMR (CDCl3, 400 MHz) δ 1.52 (d, J=7.2 Hz, 3H), 3.67 (q, J=7.2 Hz, 1H), 7.15 (t, J=8.4 Hz, 1H), 7.21-7.35 (m, 5H), 7.69 (s, 1H), 7.83 (s, 1H), 7.91 (d, J=5.6 Hz, 2H), 8.68 (d, J=5.2 Hz, 2H); 13C NMR (CDCl3, 100 MHz) δ 18.9, 31.1, 42.7, 48.0, 110.8, 112.2, 119.7, 120.5, 121.1, 127.7, 127.8, 128.1, 129.3, 134.3, 135.6, 141.1, 142.1, 147.7, 148.4, 149.1, 150.8, 161.4, 172.9; ESI-HRMS for C21H18N3O2(M+H)+ calcd. 344.1399. found 344.1397 purity (% ee >99, tR=8.07 min).

情報源と証拠