2-(Chloromethyl)anisole → 2,3-Dibromo-1-(2-methoxy-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642509ノート

反応式

HRID 642509 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:25])=[C:8]2[C:14]([Br:15])=[C:13]([Br:16])[N:12]([CH2:17][C:18]3[CH:23]=[CH:22][C:21](F)=[CH:20][CH:19]=3)[C:9]2=[CH:10][N:11]=1)=[O:5])[CH3:2].[CH2:26]([O:28]C(C1C=CNC=1C)=O)C.COC1C=CC=CC=1CCl>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:25])=[C:8]2[C:14]([Br:15])=[C:13]([Br:16])[N:12]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:28][CH3:26])[C:9]2=[CH:10][N:11]=1)=[O:5])[CH3:2]

参加物

4

反応物 3

HCID 814952-(Chloromethyl)anisoleHCID 136747Ethyl 2-methyl-3-pyrrolecarboxylateHCID 598558191h-Pyrrolo[2,3-c]pyridine-5-carboxylic acid,2,3-dibromo-1-[(4-fluorophenyl)methyl]-4-hydroxy-,ethyl ester

生成物 1

HCID 684274732,3-Dibromo-1-(2-methoxy-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

実験手順

Prepared similarly according to a reaction sequence in Example 117 steps (a), (b), (c) and (d) for the synthesis of 2,3-dibromo-1-(4-fluoro-benzyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester starting from 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester, 2-methoxybenzyl chloride. The title compound, ESI MS (m/z): 483 (M+H)+.

後処理

  1. customPrepared similarly

出典と根拠

ORDレコード
ord-8f711c29a8e0400ea89c90788cdc608e
出典データセット
uspto-grants-2010_04
特許番号
US07696223B2

反応ノート

読み込み中…