Dimethylamine → 3-Dimethylcarbamoylmethyl-5-fluoro-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-1H-indole-2-carboxylic acid
反応式
[C:1]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[N:7]([CH2:15][C:16]2[C:17]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=3[S:19][CH:20]=2)[C:6]=1[C:26]([OH:28])=[O:27])(O)=[O:2].FC1C=C2[C:36](=CC=1)[N:35](CC1C3C=C(F)C=CC=3SC=1)[C:34]1C(=O)OC(=O)CC2=1.CNC>>[CH3:34][N:35]([CH3:36])[C:1]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[N:7]([CH2:15][C:16]2[C:17]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=3[S:19][CH:20]=2)[C:6]=1[C:26]([OH:28])=[O:27])=[O:2]参加物
4
反応物 3
生成物 1
実験手順
3-Carboxymethyl-5-fluoro-1-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-1H-indole-2-carboxylic acid (from Example 60) was converted to 6-fluoro-9-(5-fluoro-benzo[b]thiophen-3-ylmethyl)-4,9-dihydro-pyrano[3,4-b]indole-1,3-dione as described in Example 68.1. which was reacted with dimethyl amine as described in Example 68.2. to give the title compound as a white solid. MS: 427.2 ([M−H]−).