1-(Bromomethyl)naphthalene → 4-naphthalen-1-ylmethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid methyl ester

HRID 642732

反応式

HRID 642732 の反応式
[O:1]1[C:8]2[CH:7]=[C:6]([C:9]([O:11][CH3:12])=[O:10])[NH:5][C:4]=2[CH:3]=[CH:2]1.Br[CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][CH:16]=1>>[CH3:12][O:11][C:9]([C:6]1[N:5]([CH2:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)[C:4]2[CH:3]=[CH:2][O:1][C:8]=2[CH:7]=1)=[O:10]

参加物

3

反応物 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 5082263methyl 4H-furo[3,2-b]pyrrole-5-carboxylate

生成物 1

HCID 685783754-naphthalen-1-ylmethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid methyl ester

実験手順

Using general procedure B, methyl 4H-furo[3,2-b]pyrrole-5-carboxylate was coupled with 1-bromomethyl-naphthalene to give 4-naphthalen-1-ylmethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid methyl ester which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a white solid. MS: 290.3 ([M−H]−).

出典と根拠

ORDレコード
ord-bb278b302aeb4704a885339d4c679062
出典データセット
uspto-grants-2010_04
特許番号
US07696240B2

関連ノート

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