関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | 2-Chloro-4-(hydroxymethyl)-3-methylbenzonitrile | HCID 68577571 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Bromomethyl)-2-chloro-3-methylbenzonitrile | HCID 68577413 | — |
反応手順
To a solution of compound 7B (700 mg, 3.9 mmol) in CH2Cl2 (15 mL) was added PBr3 (5.8 mL, 5.8 mmol, 1N in CH2Cl2) at −15° C., and stirred at −15° C. for 3 hr. The reaction was slowly quenched with saturated NaHCO3 solution at −15° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07696241B2 |
|---|
| 出典データセット | uspto-grants-2010_04 |
|---|
| ORD ID | ord-a46c7acaaea94ee58f98a39797973cdf |
|---|
| 出典メモ | uspto-grants-2010_04 |
|---|
