2-Methoxy-[1,1'-biphenyl]-4-amine → Racemic 3-{4-[1-(2-methoxy-biphenyl-4-ylamino)-hexyl]-benzoylamino}-propionic acid

反応式

C[O:2][C:3](=[O:22])[CH2:4][CH2:5][NH:6][C:7](=[O:21])[C:8]1[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:10][CH:9]=1.[CH3:23][O:24][C:25]1[CH:30]=[C:29]([NH2:31])[CH:28]=[CH:27][C:26]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH3:23][O:24][C:25]1[CH:30]=[C:29]([NH:31][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:22])=[O:21])=[CH:9][CH:10]=2)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH:28]=[CH:27][C:26]=1[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

参加物

反応物 2

HCID 5217732-Methoxy-[1,1'-biphenyl]-4-amine

HCID 67484898HCID 67484898、化合物

生成物 1

HCID 24760124Racemic 3-{4-[1-(2-methoxy-biphenyl-4-ylamino)-hexyl]-benzoylamino}-propionic acid

実験手順

The title compound is prepared by the general method exemplified in Example 1 using 3-(4-hexanoyl-benzoylamino)-propionic acid methyl ester (Preparation 5) and 2-methoxy-biphenyl-4-ylamine as starting materials. MS (ES): 475.2 [M+H]+.

出典と根拠

ORDレコード: ord-1bf802784377494d86e0e310a333256c
出典データセット: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07696248B2

反応ノート

読み込み中…