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3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole → (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole | HCID 86614009 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine | HCID 65805535 | 84.1% |
反応手順
A mixture of 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole (100 mg, 0.31 mmol) and Ra—Ni (50% aq. slurry, 150 mg) in MeOH (8 mL) was hydrogenated under balloon H2 for 3 hrs. It was filtered through celite. The filtrate was concentrated in vacuo to give (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine (78 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07696352B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-a56343b3dbb74dd782d128e53a759453 |
| 出典メモ | uspto-grants-2010_04 |