Acetic Acid → [4-({[3-(8-Methyl-3-phenylcinnolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid

HRID 643296ノート

反応式

HRID 643296 の反応式
C[O:2][C:3](=[O:36])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]3[C:28]4[C:23](=[C:24]([CH3:29])[CH:25]=[CH:26][CH:27]=4)[N:22]=[N:21][C:20]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:14]=2)=[CH:7][CH:6]=1.O.[OH-].[Li+].C(O)(=O)C>C1COCC1.CO.O>[CH3:29][C:24]1[CH:25]=[CH:26][CH:27]=[C:28]2[C:23]=1[N:22]=[N:21][C:20]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[C:19]2[C:15]1[CH:14]=[C:13]([NH:12][CH2:11][C:8]2[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:36])=[O:2])=[CH:6][CH:7]=2)[CH:18]=[CH:17][CH:16]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 168937Lithium hydroxide, monohydrateHCID 68579431(4-{[3-(8-Methyl-3-phenyl-cinnolin-4-yl)-phenylamino]-methyl}-phenyl)-acetic acid methyl ester

生成物 1

HCID 11856166[4-({[3-(8-Methyl-3-phenylcinnolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid収率 43%

試薬・触媒・溶媒 1

HCID 21892291Methanol tetrahydrofuran water溶媒

反応条件

温度
40 °C

実験手順

To a stirred solution of (4-{[3-(8-methyl-3-phenyl-cinnolin-4-yl)-phenylamino]-methyl}-phenyl)-acetic acid methyl ester in THF/methanol/water (2:1:1, 10 mL) was added lithium hydroxide monohydrate (0.1 g). The reaction was stirred at 40° C. for 1 hour. The reaction mixture was made acidic (pH 6) with glacial acetic acid, and the solid was collected and dried over P2O5 to give the title compound as an orange solid (0.02 g, 43% for Step 5 and Step 6). MS (ESI) m/z 460; HRMS (ESI, [M+H]+) 460.2012.

後処理

  1. customthe solid was collected
  2. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-9c57935b3a274c209ffd398cdf61191f
出典データセット
uspto-grants-2010_04
特許番号
US07700595B2

反応ノート

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