Ammonia → 3-Methoxy-2,7-naphthyridine

HRID 643496ノート

反応式

HRID 643496 の反応式
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([C:11]#[C:12][Si](C)(C)C)[C:6]([CH:7]=O)=[CH:5][N:4]=1.[NH3:17]>CO>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]2[C:9]([CH:10]=1)=[CH:11][CH:12]=[N:17][CH:7]=2

参加物

4

反応物 2

HCID 222AmmoniaHCID 59164393HCID 59164393、化合物

生成物 1

HCID 591643983-Methoxy-2,7-naphthyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6-Methoxy-4-[(trimethylsilyl)ethynyl]nicotinaldehyde (0.25 g, 1.1 mmol) and 7M ammonia in MeOH (5 mL) were stirred in a sealed vial at 80° C. overnight. The solution was concentrated, taken up in saturated sodium carbonate and extracted with ether. The organic phase was dried, filtered and concentrated to give 0.20 g of the title product.

後処理

  1. concentrationThe solution was concentrated
  2. extractionextracted with ether
  3. customThe organic phase was dried
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-4cc53a28afca4c0490242e58570f34b0
出典データセット
uspto-grants-2010_04
特許番号
US07700604B2

反応ノート

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