HCID 68579161、化合物 → Cysteine Protease inhibitor

HRID 643497ノート

反応式

HRID 643497 の反応式
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[N:23]=3)[CH:16]=2)=[CH:11][CH:10]=1)(C)(C)C>C(O)=O>[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28]#[N:29])[N:23]=3)[CH:16]=2)=[CH:11][CH:10]=1

参加物

3

反応物 1

HCID 68579161HCID 68579161、化合物

生成物 1

HCID 12000657Cysteine Protease inhibitor

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

A solution of [3′-(2-cyano-pyrimidin-4-yloxy)-biphenyl-4-ylmethyl]-carbamic acid tert-butyl ester (10 mg) in formic acid (0.154 ml) is stirred at rt for 1 h. This solution is evaporated under reduced pressure. The remaining oil is treated with diethyl ether to obtain crystals of 4-(4′-aminomethyl-biphenyl-3-yloxy)-pyrimidine-2-carbonitrile as salt with formic acid.

後処理

  1. customThis solution is evaporated under reduced pressure
  2. additionThe remaining oil is treated with diethyl ether

出典と根拠

ORDレコード
ord-c73d254753694664a3b2da5a0731dd8b
出典データセット
uspto-grants-2010_04
特許番号
US07700605B2

反応ノート

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