Hydrochloric Acid → Methyl 2,2-dimethyl-3-piperidin-4-ylpropanoate hydrochloride

HRID 643570ノート

反応式

HRID 643570 の反応式
[CH3:1][O:2][C:3](=[O:21])[C:4]([CH3:20])([CH3:19])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:19][C:4]([CH3:20])([CH2:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[C:3]([O:2][CH3:1])=[O:21]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 592610682,2-dimethyl-3-(N-Boc-piperidine-4-yl)-propionic acid methyl ester

生成物 1

HCID 68533965Methyl 2,2-dimethyl-3-piperidin-4-ylpropanoate hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

tert-Butyl 4-(3-methoxy-2,2-dimethyl-3-oxopropyl)piperidine-1-carboxylate (1.40 g, 4.67 mmol) was dissolved in anhydrous 4N HCl in dioxane (10 mL) and the resulting solution was stirred at rt for 1 h. The reaction mixture was concentrated to afford methyl 2,2-dimethyl-3-piperidin-4-ylpropanoate hydrochloride.

後処理

  1. concentrationThe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-c3645168c6924c239b26cf6446030d71
出典データセット
uspto-grants-2010_04
特許番号
US07700591B2

反応ノート

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