反応式
O[CH:2]=[C:3]1[CH2:11][CH2:10][CH:9]2[CH:5]([CH:6]=[N:7][N:8]2[CH3:12])[C:4]1=O.[OH:14][C:15]1[CH:16]=[C:17]([NH:21][C:22]([NH2:24])=[NH:23])[CH:18]=[CH:19][CH:20]=1>CN(C=O)C>[CH3:12][N:8]1[C:9]2[CH2:10][CH2:11][C:3]3[CH:2]=[N:23][C:22]([NH:21][C:17]4[CH:16]=[C:15]([OH:14])[CH:20]=[CH:19][CH:18]=4)=[N:24][C:4]=3[C:5]=2[CH:6]=[N:7]1参加物
4
反応条件
- 温度
- 100 °C
実験手順
To the DMF solution of crude 5-hydroxymethylene-1-methyl-1,3a,5,6,7,7a-hexahydro-indazol-4-one was added 10 eq of N-(3-hydroxy-phenyl)-guanidine, the reaction mixture was stirred at 100° C. for overnight, LC/MS indicated one of the two peaks is the desired product. The DMF solution of reaction mixture was directly injected into prep HPLC, only a portion of the product mixture was purified.
出典と根拠
- ORDレコード
- ord-5e1460234b744c78af242c55d5888b8f
- 出典データセット
- uspto-grants-2010_04
- 特許番号
- US07700609B2
関連ノート
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