Ammonium Hydroxide → Levobupivacaine

HRID 643763ノート

反応式

HRID 643763 の反応式
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.C(C(C(C([O-])=O)O)O)([O-])=O.[OH-].[NH4+]>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[C@H:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 86591002Levobupivacaine tartrate

生成物 1

HCID 92253Levobupivacaine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

45 g of levobupivacaine tartrate were dissolved in 222 mL of water under stirring. Concentrated ammonium hydroxide was added under stirring until the pH adjusted at 9-10. The solids were filtered and washed with 222 mL of water. The solids were dried in an oven with temperature around 45° C. until constant weight. Yield 27.6 g of enriched levobupivacaine free base (70%≦ee≦80%), MP=125-132° C.

後処理

  1. stirringunder stirring until the pH
  2. filtrationThe solids were filtered
  3. washwashed with 222 mL of water
  4. customThe solids were dried in an oven with temperature around 45° C. until constant weight

出典と根拠

ORDレコード
ord-73b4d2ebe2184472a1829a8c3c010dc1
出典データセット
uspto-grants-2010_04
特許番号
US07700629B2

反応ノート

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