Bromopyruvic Acid → 2-(Isopropylamino)thiazole-4-carboxylic acid hydrobromide

HRID 643821ノート

反応式

HRID 643821 の反応式
[CH:1]([NH:4][C:5]([NH2:7])=[S:6])([CH3:3])[CH3:2].[Br:8][CH2:9][C:10](=O)[C:11]([OH:13])=[O:12]>O1CCOCC1>[BrH:8].[CH:1]([NH:4][C:5]1[S:6][CH:9]=[C:10]([C:11]([OH:13])=[O:12])[N:7]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 70684Bromopyruvic AcidHCID 1711921Urea, 1-isopropyl-2-thio-

生成物 1

HCID 119534892-(Isopropylamino)thiazole-4-carboxylic acid hydrobromide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

A suspension of compound 9 (2.1 g, 18 mmol) and 3-bromopyruvic acid (3.0 g, 18 mmol) in dioxane (180 mL) was heated to 80° C. Upon reaching 80° C. the mixture became clear, and soon thereafter the product started to precipitate as a white solid. After 2 h of heating, the reaction mixture was cooled to rt and the precipitate was filtered off and collected. This yielded pure title compound (4.4 g, 94%).

後処理

  1. customUpon reaching 80° C.
  2. customto precipitate as a white solid
  3. temperatureAfter 2 h of heating
  4. temperaturethe reaction mixture was cooled to rt
  5. filtrationthe precipitate was filtered off
  6. customcollected

出典と根拠

ORDレコード
ord-3ba9ce36669844d78c4a8f5bac9e6f5e
出典データセット
uspto-grants-2010_04
特許番号
US07700552B2

反応ノート

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