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HRID 644173作成日：2026年10月25日

Piperidine → 2-[4-(piperidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide

https://huagongshe.com/reaction/644173

反応式

関与物質

役割名称HCID仕込み量
反応物PiperidineHCID 8082—
反応物2-[4-Fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamideHCID 68530207—
生成物2-[4-(piperidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamideHCID 5786086944%

反応条件

温度106 °C

反応手順

Using methods substantially equivalent to those described in example 4-F except that the reaction was heated to 106° C., 2-[4-(piperidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide (200 mg, 0.32 mmol, 44%) was prepared from 2-[4-fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-benzoylamino]-N-(5-chloropyridin-2-yl)benzamide and piperidine.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07700628B2
出典データセットuspto-grants-2010_04
ORD IDord-bdad8d63eb9c4995a290361eb616064b
出典メモuspto-grants-2010_04